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AZITHROMYCIN, 250mg/tab, 6 tabs, Teva/Sandoz, Canada

AZITHROMYCIN, 250mg/tab, 6 tabs, Teva/Sandoz, Canada

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Azithromycin is taken orally, 1 hour before or 2 hours after eating once a day.
Adults with infections of the upper and lower respiratory tract should take 500 mg / day at one intake during 3 days (course dose - 1.5 g).
For treatment of skin and soft tissues infections - 1000 mg / day on the first day for one intake, then 500 mg / day every day from 2 to 5 days (course dose - 3 g).
For treatment of acute infections of urinary organs (uncomplicated urethritis or cervicitis) - 1000 mg (one dose).
For Lyme disease (borreliosis) treatment stage I (erythema migrans) - 1000 mg at first day and 500 mg daily during 2 to 5 days (course dose - 3 g).
For treatment of gastric and duodenal ulcers associated with Helicobacter pylori the recommended dose is 1 g / day for 3 days in combination with anti helicobacter therapy.
Children older than 12 years (with a body weight of 50 kg or more) with infections of the upper and lower respiratory tract, skin and soft tissue - 500 mg one time per day for 3 days.
For the treatment of erythema migrans in children the normal dose is 1000 mg on the first day and 500 mg daily for 2 to 5 days.
Pharmacologic effect:
Azithromycin – is an antibiotic with a broad spectrum of action. It belongs to the subgroup of macrolide antibiotics - azalides, acts as bacteriostatic. At high concentrations of inflammation, it exerts a bactericidal effect.
It affects extra-and intracellular pathogens. Gram-positive microorganisms are sensitive to Azithromycin.
Side effects:
Gastrointestinal tract: diarrhea (5%); nausea (3%); abdominal pain (3%); 1% or less - indigestion (flatulence, vomiting), melena, cholestatic jaundice, increased activity of liver transaminases; in children - constipation, anorexia, gastritis; change in taste, candidiasis of the oral mucosa (1% or less).
Cardiovascular system: heart rate, chest pain (1% or less).
Nervous system: dizziness, headache, drowsiness; in children - headache (during the treatment of otitis), hyperkinesia, anxiety, neurosis, insomnia (1% or less).
Genitourinary system: vaginal candidiasis, nephritis (1% or less).
Allergic reactions: rash, angioedema, itching, hives; in children - conjunctivitis, pruritus, urticaria.
Other: fatigue, photosensitivity.
At overdose severe nausea, temporary hearing loss, vomiting, diarrhea may appear.
Treatment - immediate gastric lavage and symptomatic treatment.
Special instructions:
If you missed dose intake, the missed dose should be taken as soon as possible, and the next after 24 hours.
Take a break of 2 hours, in case of antacids use.
After discontinuation of treatment hypersensitivity reactions may persist, this requires specific therapy under medical supervision.
Combination:
Antacids (aluminum and magnesium), alcohol and food slow down and reduce the absorption of azithromycin.
If you’re prescribed with warfarin along with azithromycin (at normal doses) no changes in prothrombin time were revealed, however, taking into account the interaction of ivarfarin macrolides may increase anticoagulant effect, patients should control prothrombin time.
Increases concentration of digoxin by weakening its inactivation by intestinal flora.
Ergotamine and dihydroergotamine: strengthening of the toxic effect (vasospasm, dysesthesia).
Triazolam: decrease in clearance and an increase of the triazolam pharmacological action.
Slows down withdrawal and increases concentration and toxicity in plasma of cycloserine, indirect anticoagulants, methylprednisolone, felodipine and drugs undergoing microsomal oxidation (carbamazepine, terfenadine, cyclosporine, geksobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine, phenytoin, oral hypoglycemic drugs, theophylline, etc. xanthine derivatives) by inhibiting microsomal oxidation in hepatocytes.
Lincosamides weaken, but tetracycline and chloramphenicol enhance the effectiveness of azithromycin.
Contraindications:
Hypersensitivity (including macrolide), liver and / or kidney failure, lactation, children under 12 years.
The drug should be prescribed with caution to females during pregnancy; in cases of arrhythmia; children with liver and / or kidneys disorders.